Since joining HKRep in 2001, Karrie Tan has taken part in more than 100 productions. Recent productions include The Diary of Song 2026, A Family Story, The Story of K City, The Tamed and the Tempted, The Absolute Task, After Life, Stay with the Flow, The Doctor, Moscow Express and Sœurs. She has also participated in drama education and serves as Project Artistic Supervisor for the Jockey Club ‘Sing Out’ Character Education Musical Project. She is also a member of the China Theatre Association.
 
She was awarded Best Actress (Tragedy/Drama) for Marriage at the Hong Kong Drama Awards in 2016, and Best Supporting Actress (Tragedy/Drama) for The Professor in 2014. In 2000, her performance in Steel Magnolias won her Best Supporting Actress (Tragedy/Drama) at the Hong Kong Drama Awards. She was nominated for Outstanding Actress at the 2^nd and the 14^th Hong Kong Theatre Libre Awards for The Labels and Sœurs respectively. Karrie has frequently been nominated for Best Actress or Best Supporting Actress at the Hong Kong Drama Awards.
 

In addition, her innovative creations and performances in HKRep Black Box — Those were the Days, The Labels (also as Deputy Director), A Hollow Room (also as Director), have earned her considerable critical acclaim. In 2013, she collaborated with the Radiant Theatre as playwright and director of The Mixed Doubles, which was selected among the Top Ten Most Popular Productions at the 23^rd Hong Kong Drama Awards. A Giant Cookie, a black box production that she wrote and directed, was nominated for Best Script at the 7^th Hong Kong Theatre Libre in 2014.
  

In 2009, Karrie received a Sir Robert Black Trust Fund Postgraduate Scholarships and studied at the Birmingham School of Acting, where she obtained a Master’s degree in Drama with first-class honours. She was selected a Rising Star by The Stage (Theatre news). During her studies in the United Kingdom, she took part in productions including Troilus and Cressida (as Cressida / Helen of Troy), Hedda Gabler (as Hedda) and The House of Yes (as Lesly)。
 

Apart from her stage appearances, Tan has appeared in commercials and television programmes. She was also a Cantonese voice artist for Disney, voicing Susan Pevensie in the  The Chronicles of Narnia: The Lion, the Witch and the Wardrobe. She also appeared in RTHK's Artspiration, A Wall-less World (the 5^th episode), as well as ViuTV's Craft a Live.